Friday, March 9, 2012

Nuclear Hormone Receptors in Skin


Nuclear hormone receptors (NHR) act as transcription factors by directly binding to DNA and initiating the transcription of genes. They play an important role in tissue homeostasis by modulating critical cell functions such as metabolism, proliferation, differentiation, cell death and inflammation. This study was designed to determine patterns of NHR expression in skin under physiologic and pathologic conditions. The results reveal a specific expression pattern in normal skin as well as disease specific expression patterns for psoriasis and atopic dermatitis. While the increa
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